Poison's Greatest Hits: 1986–1996

Poison's Greatest Hits: 1986–1996 is the first greatest hits compilation CD by the glam metal band Poison, released on November 26, 1996, by Capitol Records to celebrate the band's 10th anniversary. The album contains 16 tracks from the band's first four studio albums (Look What the Cat Dragged In, Open Up and Say... Ahh!, Flesh & Blood and Native Tongue) and also the live double-album Swallow This Live.

The compilation charted at number 2 on the Top Catalog Albums chart in Billboard magazine and includes most of Poison's hit singles which charted on the Billboard Hot 100 or mainstream rock charts. The compilation was certified Gold in 1999 and by 2005 the album had gone double platinum. It was certified gold in Canada.