The Best of Poison: 20 Years of Rock

The Best of Poison: 20 Years of Rock is a compilation album from the American glam metal band Poison, released by Capitol Records on April 3, 2006, to celebrate the band's 20th anniversary. It sold more than one million copies to date in the U.S. as of September 2009.

The album was produced by Don Was and marked Poison's return to the Billboard 200 top 20 charts for the first time since 1993. The compilation debuted at No. 17, quite an impressive showing for a hair metal band in 2006, and perhaps showing the beneficial effect of many Behind the Music-type shows on VH1, where Poison's hair metal antics were relived. The album also charted at No. 5 on the Top Rock Albums, No. 4 on the Top Catalog Albums and No. 10 on the Top Hard Rock Albums chart.

The Best of Poison: 20 Years of Rock was certified Gold in 2006 by the RIAA.